|
KMID : 0354719930170010045
|
|
Journal of Korean Diabetes Association
1993 Volume.17 No. 1 p.45 ~ p.50
|
|
|
Low Frequencies of Human Gytomegalovirus(hCMV) Genome in Diabetic Patients
|
|
이석인
고경수/박경수/홍성관/김성연/조보연/이홍규/고창순/민헌기
|
|
|
Abstract
|
|
|
Background :
@EN Human cytomegalovirus (hCMV) is ubiquitous and often infects the host persistently. The role of hCMV in the pathogenesis of diabetes has been suggested, being the genome detected in the peripheral leukocytes of newly onset Type 1 diabetic
patients
and in the pancreatic tissues of Type 2 diabetic patients. But a contrary result was followed.
@ES Methods:
@EN To investigate the possible role of hCMV genome in the pathogenesis of diabetes, we screeened the hCMV genome in the peripheral leukocytes of 28 Type 1 and 58 Type 2 diabetic patients and the genome in the pancreatic tissues of 12 diabetic
patients.
We amplified the extracted DNA by polymerase chain reaction (PCR) priming immediate early gene of the hCMV which is specific for the viral genome. Also we confirmed it by dot-blot hybridization.
@ES Results:
@EN In peripheral leukocytes, the hCMV genome was detected in one of 28 Type 1 diabetic patients and one of 58 Type 2 diabetic patients and none was detected in the 38 healthy controls. In the pancreas, the genome was detected in one of 12
diabetic
patients and three of 45 non-diabetic patients.
@ES Conclusion:
@EN With these-results, the persistent hCMV infections may not have a role in the pathogenesis of diabetes in Korean patients.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|